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Therapeutic Apheresis Technology

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Products «Immunoadsorption columns Ig Adsopak»

Immunoglobulins (Ig) and circulating immune complexes (CIC) are known to be pathologic or immune suppressive in many autoimmune diseases and certain cancers. The immunoadsorption columns Ig Adsopak® is original product for direct and selective removal of Ig and CIC.

 

The therapy with Ig Adsopak® columns, called Ig-apheresis has following indications:

 

organ transplantation
The patients expecting renal transplantation demonstrate the increased amount of antibodies against human lymphocyte antigens (HLA). Removal of anti-HLA antibodies before and after the renal transplantation increases successful result of the operation.

hematological diseases
Factor VIII antibodies may arise hemophilia as a consequence of replacement therapy or may occur spontaneously in patients with previously normal coagulation. Treatment of such patients is difficult in case of serious bleeding or if surgery is required, since conventional doses of human factor VIII concentrates is ineffective. Ig-apheresis is promising method to achieve a fast elimination of factor VIII autoantibodies.

neurological diseases
Increased amount of IgA and IgM antibodies were found in plasma of patients suffering from Guillain-Barre syndrome, dimielinating neuropathy and multiple sclerosis The autoantibodies blocking acetylcholine receptors play a key role in development of myasthenia gravies. The specific removal of pathogenic antibodies by Ig apheresis was demonstrated to be affective in these cases.

rheumatoid diseases
CIC and pathologic Ig occur in most of autoimmune disorders including rheumatoid arthritis, systemic lupus erythematosus, glomerulonephritis, thrombocytopenic purpura. Results of animal studies show the therapeutic effects of treatment by Ig-apheresis.

cardiovascular diseases
Some characteristics of dilated cardiomyopathy and miocarditis suppose the involvement of autoimmune processes into pathogenesis.70-90% of dilated cardiomyopathy occasions are characterized by presence of pathologic autoantibodies. Significant improvement of heart patient’s condition were observed due to reduction of Ig level by Ig apheresis procedure.